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Join our teams in the Netherlands and Italy and contribute to the development of First Health Pharmaceuticals´ antiviral and anticancer compounds through state of the art and RNA technology-driven R&D strategy.

Medicinal Chemist Intern, Location: Colle di Val d'Elsa (SI), Italy

Internship summary:
The First Health Pharmaceutical Laboratory works on the development of new chemical entities with biological activity as part of a research and development platform involving biologists, chemists and pharmacologist, with the objective to find the cure for viral.

The Medicinal Chemistry Internship will immerse the candidate in a broad range of chemical, analytical methods including NMR and LC-MS spectroscopy. Under direction, the candidate will participate to the complete process of synthesis and purification of new chemical entities. Reporting the results to an interdisciplinary team of scientist. This position consist of a minimum 12-week internship located in the First Health Pharmaceutical Laboratory (Colle di Val d’Elsa-SIENA, Italy).

Activities:

  • Analytical mindset
  • Strong oral and written communication skills
  • Intellectually curious with a driving interest in Medicinal Chemistry

Requirements:
Master of Science or PhD student in Chemistry or Medicinal Chemistry. A solid knowledge of Chemistry and a basic experience in organic synthesis.

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Junior Medicinal Chemist, Location: Colle di Val d'Elsa (SI), Italy

Open position summary:
The Medicinal Chemistry Team is part of the Research and Development Unit located in Colle di Val d’Elsa (Siena, Italy). The team is focused on the design, synthesis and purification of new chemical entities, as part of a articulate drug discovery pipeline with the final objective of identify and optimize new bioactive molecules for treating diseases with unmet medical need.


As Junior Medicinal chemist, under supervision, you will contribute to the development of the best medicinal chemistry strategies to synthesize molecules that will be evaluated for biological activity within the research projects of First Health Pharmaceuticals with the final objective to identify clinical candidates. The candidate should demonstrate creativity, curiosity and good interpersonal skills.

Activities

  • Perform instrumental analysis of synthesized compounds with techniques LCMS, HPLC and NMR
  • Design and execution of multi-step synthesis accordingly with project timeline.
  • Preparation of reports about the work performed for presentations
  • Maintain track records of experimental procedure and work in laboratory notebook

Requirements

  • Master of Science in Chemistry or Pharmaceutical chemistry, with experimental thesis in organic synthesis.
  • Knowledge of Microsoft Office and software for the design of chemical structures.
  • Knowledge of at least LC-MS, NMR techniques.
  • Experience with multi step synthesis, purification and characterization of organic compounds.

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DMPK/ADME-Tox Expert (full time, location, Siena - Italy)

Requirements:

  • PhD or relevant experience in Pharmacokinetics, Pharmacology, Toxicology or related disciplines
  • Experience with in vitro and in vivo studies : design and performing
  • Ability to design study protocols and to select activities and compounds based on results
  • Ability to design and perform the laboratory activities independently
  • Knowledge of relevant regulatory requirements

Regulatory affairs Specialist (full or part time, location, Amsterdam - The
Netherlands)

Requirements

  • PhD or Master degree or relevant experience in Regulatory Affairs for clinical development
  • Proven experience in CTA/ IND submission and document writing
  • Experience in collaborations with CRO
  • Experience in Scientific Advice with the EMA

Please submit your resume to work@firsthealthpharma.com